Carcinogenic Effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in Male Wistar Rats: Promotion of Pancreatic Cancer by a Raw Soya Flour Diet

D. A. Levison Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland

R. G. H. Morgan Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland

J. S. Brimacombe Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland

D. Hopwood Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland

G. Coghill Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland

K. G. Wormsley Depts. of Pathology, Chemistry, and Therapeutics, University of Dundee, Dundee, Scotland

Abstract

Di(2-hydroxypropyl)nitrosamine was administered to rats fed raw or heated (control) soya flour diets. The group fed raw soya flour developed hyperplastic and adenomatous pancreatic nodules and pancreatic adenocarcinomata. We conclude that a diet of raw soya flour augments the carcinogenicity of pancreatic carcinogens in the rat.

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Carcinogenic Effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in Male Wistar Rats: Promotion of Pancreatic Cancer by a Raw Soya Flour Diet

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Carcinogenic Effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in Male Wistar Rats: Promotion of Pancreatic Cancer by a Raw Soya Flour Diet

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