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Original Article

Antral G- and D-cell Counts in Chronic Renal Failure

, , , , , , , & show all
Pages 327-331 | Received 18 Sep 1978, Accepted 15 Nov 1978, Published online: 23 Feb 2010
 

Abstract

Antral somatostatin-and gastrin-producing cells (D and G cells) were studied in a group of patients with chronic renal failure (CRF) in comparison with a control group. Gastric acid secretion and serum gastrin, phosphate, and parathormone (PTH) levels were also evaluated in every patient. The group with CRF showed a mild increase both in G- and in D-cell density. In this group serum phosphate and PTH levels were higher than normal, showing hyperparathyroidism in every patient. A direct correlation was found between G-cell density and parathyroid function in patients with CRF. Hyperparathyroidism, therefore, seems to play a role in the mechanism of increased serum gastrin levels in CRF.

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