A Double-blind Trial of Synthetic Salmon Calcitonin in the Treatment of Acute Pancreatitis

H. Goebell Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

R. Ammann Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

CH. Herfarth Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

J. Horn Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

J. Hotz Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

M. Knoblauch Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

M. Schmid Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

M. Jaeger Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

A. Akovbiantz Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

E. Linder Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

K. Abt Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

E. Nüesch Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

E. Barth Medical Dept., University of Essen, Essen; Surgical Dept., University of Ulm, Ulm; and Dept. Biomathematics, Medical School, University of Frankfurt, Frankfurt a.M; West Germany; and Medical Dept. and Surgical Dept., University Hospital, and Medical Dept. and Surgical Dept., Waidhospital, Zurich; and Medical Division, Sandoz A.G., Basel; Switzerland

& The Pancreatitis Study Group show all

Abstract

A multicenter randomized double-blind trial on the use of synthetic salmon calcitonin (SCT) was carried out in 94 patients with acute pancreatitis. In addition to strict standard treatment—without aprotinin, atropine, or antacids—50 patients received daily 3 × 20 μg = 300 MRCU SCT intravenously and 44 patients received placebo for 6 days. Mortality rate was not influenced, overall mortality being 5.3%. The number of patients without pain and with normalized serum amylase on a given day was significantly higher in the group treated with SCT. Other parameters such as doses of analgesics, leukocyte count, and normalization of seven defined clinical and laboratory criteria within 6 days showed a positive trend without reaching significance.

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A Double-blind Trial of Synthetic Salmon Calcitonin in the Treatment of Acute Pancreatitis

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A Double-blind Trial of Synthetic Salmon Calcitonin in the Treatment of Acute Pancreatitis

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