The Effects of Phthalylsulphathiazole on the Bacteria of the Colonic Mucosa and Intestinal Contents as Revealed by the Examination of Surgical Samples

C. G. Marks St. Mark's Hospital for Diseases of the Colon and Rectum, and Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, Colindale, London, England

P. R. Hawley St. Mark's Hospital for Diseases of the Colon and Rectum, and Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, Colindale, London, England

S. L. Peach St. Mark's Hospital for Diseases of the Colon and Rectum, and Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, Colindale, London, England

B. S. Drasar St. Mark's Hospital for Diseases of the Colon and Rectum, and Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, Colindale, London, England

M. J. Hill St. Mark's Hospital for Diseases of the Colon and Rectum, and Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, Colindale, London, England

Abstract

The isolation of a bacterial flora specifically associated with the colonic mucosa of patients undergoing large-bowel surgery is described. This flora differed from that of faeces in both the numbers and the types of bacteria isolated. The most striking difference was the reduction in the number of anaerobic bacteria isolated from the colonic mucosa. The ratio of anaerobic to aerobic was approximately 1:1 for mucosa compared with 100:1 for faeces.

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The Effects of Phthalylsulphathiazole on the Bacteria of the Colonic Mucosa and Intestinal Contents as Revealed by the Examination of Surgical Samples

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The Effects of Phthalylsulphathiazole on the Bacteria of the Colonic Mucosa and Intestinal Contents as Revealed by the Examination of Surgical Samples

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