Histamine H₂ Receptors and Intrinsic Factor Secretion

P. C. Sharpe Research Institute, Smith Kline & French Research Limited, Welwyn Garden City, Hertfordshire; Dept. of Haematology, St. Bartholomew's Hospital, London; and Royal Naval Hospital, Haslar, Gosport, Hampshire, U.K.

J. G. Mills Research Institute, Smith Kline & French Research Limited, Welwyn Garden City, Hertfordshire; Dept. of Haematology, St. Bartholomew's Hospital, London; and Royal Naval Hospital, Haslar, Gosport, Hampshire, U.K.

M. A. Horton Research Institute, Smith Kline & French Research Limited, Welwyn Garden City, Hertfordshire; Dept. of Haematology, St. Bartholomew's Hospital, London; and Royal Naval Hospital, Haslar, Gosport, Hampshire, U.K.

R. H. Hunt Research Institute, Smith Kline & French Research Limited, Welwyn Garden City, Hertfordshire; Dept. of Haematology, St. Bartholomew's Hospital, London; and Royal Naval Hospital, Haslar, Gosport, Hampshire, U.K.

S. H. Vincent Research Institute, Smith Kline & French Research Limited, Welwyn Garden City, Hertfordshire; Dept. of Haematology, St. Bartholomew's Hospital, London; and Royal Naval Hospital, Haslar, Gosport, Hampshire, U.K.

G. J. Milton-Thompson Research Institute, Smith Kline & French Research Limited, Welwyn Garden City, Hertfordshire; Dept. of Haematology, St. Bartholomew's Hospital, London; and Royal Naval Hospital, Haslar, Gosport, Hampshire, U.K.

Abstract

Intrinsic factor (IF) secretion in healthy male subjects was studied in response to pentagastrin stimulation with and without cimetidine, and to impromidine, a histamine H₂ receptor agonist. Peak and total IF output were reduced by cimetidine, but the concentration was unchanged and the response was unaffected by administration of the compound for 1 week. The IF secretory response to impromidine was similar to that to pentagastrin. It is suggested that the acid and IF components of the parietal cell secretory response are mediated via different intracellular pathways, that histamine H₂ receptors do not fulfill an obligatory role in the secretion of IF and that synthesis of IF is probably not altered by cimetidine.

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Histamine H₂ Receptors and Intrinsic Factor Secretion