Abstract
In the anaesthetized cat duodenal perfusion with Na-taurocholate (TC. 0.2 M, pH 6.1. 290 mosmol, 45 ml x h−1) stimulated pancreatic volume (0 to 326 ± 236 mg x 10 min−1) and bicarbonate secretion (0 to 34.2 ± 4.1 μmol x 10 min−1), whereas pancreatic enzyme output was sparse. Simultaneously with the pancreatic response, bile flow increased from 139 ± 74 mg to 484 ± 146 mg x 15 min−1 (p <0.05). During perfusion of the upper jejunum both pancreatic and biliary responses were significantly lower than the responses to duodenal TC perfusion (p <0.05). During TC perfusion of the terminal ileum there was no response from the pancreas, whereas the increase in bile flow accounted only for an increase in the bile-acid-dependent fraction. The concomitant stimulation of both the hydrokinetic function of the pancreas and the bile-acid-independent bile flow might be mediated by a release of secretin.