The Parietal Cells in Duodenal Ulcer Patients

A Quantitative Ultrastructural Study before and during Treatment with Cimetidine

H. Overgaard Nielsen Institute of Pathology, Dept. of Surgical and Medical Gastroenterology, Odense University Hospital, Odense, and Dept. of Surgical Gastroenterology C, Rigshospitalet, Copenhagen, Denmark

P. E. Rørbák Madsen Institute of Pathology, Dept. of Surgical and Medical Gastroenterology, Odense University Hospital, Odense, and Dept. of Surgical Gastroenterology C, Rigshospitalet, Copenhagen, Denmark

L. A. Christiansen Institute of Pathology, Dept. of Surgical and Medical Gastroenterology, Odense University Hospital, Odense, and Dept. of Surgical Gastroenterology C, Rigshospitalet, Copenhagen, Denmark

Abstract

Quantitative ultrastructural analyses of the parietal cells have been performed on eleven patients with chronic duodenal ulcer, before and after 8 weeks' treatment with a histamine H₂-receptor antagonist (Cimetidine, 1 g/day). The treatment caused a significant decrease of the secretory surface density; this result seems to differ from those of ultrastructural reports on parietal cells when acid secretion is inhibited by vagotomy. Furthermore, it was demonstrated that the profile of the tubulo-vesicles of parietal cells could be seen in three phases, tentatively suggesting that this system is able to take up material from the surrounding cytoplasm by encircling it.

Key-words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Parietal Cells in Duodenal Ulcer Patients

A Quantitative Ultrastructural Study before and during Treatment with Cimetidine

Information for

Open access

Opportunities

Help and information

The Parietal Cells in Duodenal Ulcer Patients

A Quantitative Ultrastructural Study before and during Treatment with Cimetidine

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature