The Effect of Antral Distension on the Endocrine Pancreas in Man

I.-M. Schöön Dept. of Surgery II and Dept. of Medicine I, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden; Institute of Medical Physiology, University of Copenhagen, Copenhagen, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

L. Sjöström Dept. of Surgery II and Dept. of Medicine I, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden; Institute of Medical Physiology, University of Copenhagen, Copenhagen, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

J. J. Holst Dept. of Surgery II and Dept. of Medicine I, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden; Institute of Medical Physiology, University of Copenhagen, Copenhagen, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

T. W. Schwartz Dept. of Surgery II and Dept. of Medicine I, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden; Institute of Medical Physiology, University of Copenhagen, Copenhagen, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

L. Olbe Dept. of Surgery II and Dept. of Medicine I, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden; Institute of Medical Physiology, University of Copenhagen, Copenhagen, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

Abstract

Isolated antral distension by a 150 cm³ balloon in man significantly elevated the plasma concentrations of pancreatic polypeptide and glucagon in portal venous blood. The concentrations of plasma pancreatic glucagon, plasma insulin, and plasma glucose were unchanged in peripheral venous blood during antral distension with or without a background infusion of pentagastrin. Antral distension significantly increased the plasma concentration of pancreatic polypeptide in peripheral venous blood. Antral distension also inhibited basal and pentagastrin-stimulated gastric acid secretion in healthy subjects. The release of pancreatic hormones evoked by antral distension cannot explain the concomitant inhibition of gastric acid secretion. The results support and extend the concept of a gastro-pancreatic reflex to the endocrine part of the pancreas with release of at least pancreatic polypeptide and glucagon.

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The Effect of Antral Distension on the Endocrine Pancreas in Man

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