The Effect of Duodenal Infusion of Bile on Plasma VIP, GIP, and Secretin and on Duodenal Bicarbonate Secretion

P. G. Burhol Laboratory of Gastroenterology, Dept. of Medicine, University Hospital of Tromsø, Tromsø, Norway

I. Lygren Laboratory of Gastroenterology, Dept. of Medicine, University Hospital of Tromsø, Tromsø, Norway

H. L. Waldum Laboratory of Gastroenterology, Dept. of Medicine, University Hospital of Tromsø, Tromsø, Norway

R. Jorde Laboratory of Gastroenterology, Dept. of Medicine, University Hospital of Tromsø, Tromsø, Norway

Abstract

Nine healthy young male students were studied before, during, and after a 10-min period of duodenal infusion of 6 g dried cattle bile dissolved in 75 ml distilled water to iso-osmolarity and pH adjusted to pH 7.O. Plasma vasoactive intestinal polypeptide (VIP), gastric inhibitory polypeptide (GIP), and duodenal bicarbonate secretion increased significantly, whereas plasma secretin showed a late but not significant tendency to rise after the bile infusion.

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The Effect of Duodenal Infusion of Bile on Plasma VIP, GIP, and Secretin and on Duodenal Bicarbonate Secretion

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The Effect of Duodenal Infusion of Bile on Plasma VIP, GIP, and Secretin and on Duodenal Bicarbonate Secretion

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