Effects of Intra-arterial Prostaglandin E₂ on Gallbladder Fluid Transport, Motility, and Hepatic Bile Flow in the Cat

E. Thornell Dept. of Surgery III, University of Gothenburg, Gothenburg, Sweden, and Dept. of Surgery, Kings College Hospital Medical School, University of London, London, England

J. Svanvik Dept. of Surgery III, University of Gothenburg, Gothenburg, Sweden, and Dept. of Surgery, Kings College Hospital Medical School, University of London, London, England

J. R. Wood Dept. of Surgery III, University of Gothenburg, Gothenburg, Sweden, and Dept. of Surgery, Kings College Hospital Medical School, University of London, London, England

Abstract

The effects of intra-arterial infusion of prostaglandin E₂ on gallbladder concentrating function, motility, and hepatic bile flow were studied simultaneously in the anesthetized cat by means of a perfusion technique. Prostaglandin E₂ reversibly inhibited gallbladder net fluid absorption and in some cases reversed the direction of transport to a net fluid secretion. A contraction of the gallbladder and an increased flow of hepatic bile were seen during prostaglandin infusion. The results are discussed in relation to the role of prostaglandins in the pathophysiology of cholecystitis.

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Effects of Intra-arterial Prostaglandin E₂ on Gallbladder Fluid Transport, Motility, and Hepatic Bile Flow in the Cat

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Effects of Intra-arterial Prostaglandin E2 on Gallbladder Fluid Transport, Motility, and Hepatic Bile Flow in the Cat

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Effects of Intra-arterial Prostaglandin E₂ on Gallbladder Fluid Transport, Motility, and Hepatic Bile Flow in the Cat