The Effect of Insulin-Induced Hypoglycemia with and without Atropine on Plasma Gip in Man

Abstract

Insulin-induced hypoglycemia caused a modest but significant (p = 0.031) increase in plasma GIP. This increase was significantly (p = 0.031) attenuated when atropine was given together with insulin, indicating that the vagal nerves play a major role in the release of plasma GIP during hypoglycemia.

Key-words:

• Atropine
• gastric inhibitory polypeptide (GIP)
• hypoglycemia
• vagal nerves