Inhibition of Gastrin Secretion by Pirenzepine (LS 519) in Treatment of Gastric Ulcer

Abstract

The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer. Single-dose administration of the drug caused a significant decrease in the basal gastrin level and significant inhibition of the serum gastrin response. When measured 12 h after the end of drug treatment for 7 days, the serum gastrin levels in the basal state and in response to a test meal tended to be high, but the differences were not statistically significant.

Key-words:

• Gastrin secretion
• peptic ulcer
• pirenzepine