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Original Article

Inhibition of Gastrin Secretion by Pirenzepine (LS 519) in Treatment of Gastric Ulcer

, , , , &
Pages 269-271 | Received 11 Mar 1980, Accepted 25 Jul 1980, Published online: 22 Feb 2010
 

Abstract

The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer. Single-dose administration of the drug caused a significant decrease in the basal gastrin level and significant inhibition of the serum gastrin response. When measured 12 h after the end of drug treatment for 7 days, the serum gastrin levels in the basal state and in response to a test meal tended to be high, but the differences were not statistically significant.

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