Acetazolamide Interferes with the Protective Effect of Prostaglandin E₂ in the Rat Gastric Mucosa

Abstract

Oral prostaglandin E₂ protected the gastric mucosa against the damage induced by intraperitoneal indomethacin in the rat. Blocking of the gastric alkaline secretion by subcutaneous acetazolamide potentiated the ulcerogenic action of indomethacin and reduced or abolished the protective effect of a submaximal dose prostaglandin E₂. The results are compatible with the hypothesis that stimulation of the alkaline secretion is one of the mechanisms by which prostaglandin E₂ protects the gastric mucosa.

Key-words:

• Gastric alkaline secretion
• prostaglandin E₂ rat
• stomach