Depression of Insulin Release by Anti-GIP Serum after Oral Glucose in Rats

K. B. Lauritsen Dept. of Surgical Gastroenterology, Hvidovre Hospital; Institute of Medical Physiology C, University of Copenhagen; and Novo Research Institute; Copenhagen, Denmark

J. J. Holst Dept. of Surgical Gastroenterology, Hvidovre Hospital; Institute of Medical Physiology C, University of Copenhagen; and Novo Research Institute; Copenhagen, Denmark

A. J. Moody Dept. of Surgical Gastroenterology, Hvidovre Hospital; Institute of Medical Physiology C, University of Copenhagen; and Novo Research Institute; Copenhagen, Denmark

Abstract

An oral glucose tolerance test (OGTT), an OGTT after infusion of anti-gastric inhibitory polypeptide (GIP) serum, and an intravenous glucose infusion were performed in unrestrained and unanesthetized rats. In the rats treated with anti-GIP serum the insulin release was significantly depressed. This finding supports the concept that GIP is a physiologically important ‘glucose-dependent insulin-releasing peptide’.

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Depression of Insulin Release by Anti-GIP Serum after Oral Glucose in Rats

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Depression of Insulin Release by Anti-GIP Serum after Oral Glucose in Rats

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