Infusion of Vasoactive Intestinal Polypeptide in Man: Pharmacokinetics and Effect on Gastric Acid Secretion

M. Holm-Bentzen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

J. Christiansen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

B. Petersen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

J. Fahrenkrug Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

A. Schultz Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

P. Kirkegaard Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

Abstract

Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers. On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 μg/kg-h, each dose being give for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/1 to 28, 106 and 336 pmol/1 during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.

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Infusion of Vasoactive Intestinal Polypeptide in Man: Pharmacokinetics and Effect on Gastric Acid Secretion

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