Acid Secretory Potency and Elimination of the 15-Leucine Gastrin-17 Analogue in Man

B. Petersen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Copenhagen, and the Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

J. Christiansen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Copenhagen, and the Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

J. F. Rehfeld Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Copenhagen, and the Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

Abstract

The effect on gastric acid secretion and the elimination of a commercially available synthetic human gastrin analogue (15-Leucine Synthetic Human Gastrin I, 15-LSG) were studied in six healthy human subjects. On a molar basis acid secretory efficacy was approximately four times greater than pentagastrin and secretory potency ten times greater. Elimination of 15-LSG was bi-exponential, with half-lives of 5.2 ± 0.8 and 25.9 ± 7.0 min. Metabolic clearance rate was 6.9 ± 0.4 ml/kg-min and volume of distribution 52 ml/kg.

Key-words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Acid Secretory Potency and Elimination of the 15-Leucine Gastrin-17 Analogue in Man

Information for

Open access

Opportunities

Help and information

Acid Secretory Potency and Elimination of the 15-Leucine Gastrin-17 Analogue in Man

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature