Gastric Inhibitory Polypeptide Release into the Portal Vein in Response to Intraduodenal Amino Acid Loads in Anesthetized Rats

Abstract

Gastric inhibitory polypeptide (GIP) release into the portal vein in response to duodenal instillation of amino acid (AA) solutions in doses of 1.379, 2.758, 5.516, and 11.032 mmol/kg body weight was studied in an acute male Wistar rat preparation. A rapid dose-dependent, and significant rise in portal vein plasma GIP was found in response to increasing duodenal AA loads, and this could be described by Michaelis-Menten kinetics.

Key-words:

• Amino acids, duodenal
• gastric inhibitory polypeptide (GIP)
• Michaelis-Menten kinetics
• plasma, portal vein
• rats