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Scandinavian Journal of Gastroenterology Volume 18, 1983 - Issue 2
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Original Article

The Effect of Alpha- and Beta-Receptor Blocking Agents on Gastric Acid Secretion in Guinea-Pigs

T. Gauperaa Dept. of Surgery, University Hospital of Tromsø, Tromsø, Norway
,
A. R. Green Dept. of Surgery, University Hospital of Tromsø, Tromsø, Norway
&
J. A. Johnson Dept. of Surgery, University Hospital of Tromsø, Tromsø, Norway
Pages 313-316 | Received 22 Apr 1982, Accepted 09 Aug 1982, Published online: 19 Feb 2010
 
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Abstract

The effects of alpha- and beta-receptor blocking agents on gastric acid secretion were tested on 95 female guinea-pigs. Alpha blockade insignificantly inhibited the gastric acid secretion in the unstimulated animals, whereas in those stimulated with histamine, significant reduction was seen. Beta blockade had no influence on gastric secretion in the unstimulated animals but significantly enhanced the histamine-stimulated secretion of acid.

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