Enzymatic Activities in Jejunal Biopsy Specimens from Patients with the Stagnant-Loop Syndrome

H. Schjønsby Section for Clinical Research and Molecular Medicine, Medical Dept. A, University of Bergen, Bergen, and Medical Dept. B, Aker Sykehus, University of Oslo, Oslo, Norway

K.-J. Andersen Section for Clinical Research and Molecular Medicine, Medical Dept. A, University of Bergen, Bergen, and Medical Dept. B, Aker Sykehus, University of Oslo, Oslo, Norway

K. Nordgård Section for Clinical Research and Molecular Medicine, Medical Dept. A, University of Bergen, Bergen, and Medical Dept. B, Aker Sykehus, University of Oslo, Oslo, Norway

D. W. Skagen Section for Clinical Research and Molecular Medicine, Medical Dept. A, University of Bergen, Bergen, and Medical Dept. B, Aker Sykehus, University of Oslo, Oslo, Norway

Abstract

The activity of the marker enzymes lactase, sucrase, neutral α-glucosidase, alkaline phosphatase, γ-glutamyl transferase, leucyl-β-naphthylamidase (brush border); 5-nucleotidase (basolateral membrane); and acid phosphatase and N-acetyl-β-glucosaminidase (lysosomes) in jejunal biopsies from patients with the stagnant-loop syndrome and controls was studied. The activity of γ-glutamyl transferase was increased in the patient group; the activity of the other enzymes did not differ significantly in patients and controls. The DNA to protein ratio was increased in the patient group. The results do not support the hypothesis of epithelial damage in the human stagnant-loop syndrome.

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Enzymatic Activities in Jejunal Biopsy Specimens from Patients with the Stagnant-Loop Syndrome

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Enzymatic Activities in Jejunal Biopsy Specimens from Patients with the Stagnant-Loop Syndrome

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