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Original Article

Action of Pirenzepine, A New Muscarinic Antagonist Drug, on Human Pancreatic Secretion

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Pages 990-994 | Received 17 Jul 1984, Accepted 15 Mar 1985, Published online: 08 Jul 2009
 

Abstract

The action of a new muscarinic antagonist drug on the pancreatic secretion has been studied in 12 healthy subjects. A stable pancreatic secretory plateau was obtained with submaximal hormonal stimulation (0.125 CU/kg/h secretin; 30 ng/kg/h caeru-lein). The highest dose of pirenzepine (40 mg) inhibited both volume and enzymatic concentration and output (−72.2% and −77.9% of plateau value for chymotrypsin and lipase output, respectively, 30min after pirenzepine injection). The inhibition appeared immediately, lasted for more than 60min, and was dose-related. The calcium dose-response curve paralleled those of lipase and chymotrypsin outputs. These results were comparable to those obtained with other anti-acetylcholine drugs and may be associated with the action of certain doses of ethanol on pancreatic secretion. In contrast, the lowest pirenzepine dose used (10 mg) induced a delayed stimulation of bicarbonate output, and bicarbonate concentration was not altered.

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