The Effects of Vagal Nerve Stimulation on Endoluminal Release of Serotonin and Substance P into the Feline Small Intestine

K. O. Grosnstad Dept. of Surgery, Suny, Downstate Medical Center, New York, New York, USA

L. Demagistris Dept. of Surgery, Suny, Downstate Medical Center, New York, New York, USA

A. Dahlstroum Dept. of Surgery and Institute of Neurobiology, University of Gothenburg, Gothenburg, Sweden

O. Nilsson Dept. of Surgery and Institute of Neurobiology, University of Gothenburg, Gothenburg, Sweden

B. Price Dept. of Gastroenterology, University of Rome, Rome, Italy

M. J. Zinner Dept. of Gastroenterology, University of Rome, Rome, Italy

B. M. Jaffe Dept. of Surgery, Suny, Downstate Medical Center, New York, New York, USA

H. Ahlman Dept. of Surgery, Suny, Downstate Medical Center, New York, New York, USA

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Abstract

Endoluminal release of serotonin (5-HT), substance P (SP), and motilin was quantitated after thoracic vagal nerve stimulation in the cat. In duodenum and jejunum, simultaneous release of these compounds was observed. In contrast, vagal stimulation did not augment the rate of luminal secretion of either 5-HT or SP in the distal ileum. Immunohistochemical studies demonstrated 5-HT in both enterochromaffin (EC) cells and nerves throughout the small bowel. However, we were unable to visualize any SP-containing EC cells in the cat, which suggests that the source of luminal SP in this species must be intramural nerves.

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The Effects of Vagal Nerve Stimulation on Endoluminal Release of Serotonin and Substance P into the Feline Small Intestine

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The Effects of Vagal Nerve Stimulation on Endoluminal Release of Serotonin and Substance P into the Feline Small Intestine

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