Effect of Intravenous and Intraduodenal Administration of Escherichia Coli Endotoxin on the Porcine Pancreas as Evaluated by Changes in the Serum Cationic Trypsin-Like Immunoreactivity

J. Florholmen Laboratory of Gastroenterology, Dept. of Medicine and Dept. of Surgery, University Hospital of Tromsø, and Institute of Medical Biology, University of Tromsø, Tromsø, Norway

A. Revhaug Laboratory of Gastroenterology, Dept. of Medicine and Dept. of Surgery, University Hospital of Tromsø, and Institute of Medical Biology, University of Tromsø, Tromsø, Norway

P. G. Burhol Laboratory of Gastroenterology, Dept. of Medicine and Dept. of Surgery, University Hospital of Tromsø, and Institute of Medical Biology, University of Tromsø, Tromsø, Norway

K.-E. Giercksky Laboratory of Gastroenterology, Dept. of Medicine and Dept. of Surgery, University Hospital of Tromsø, and Institute of Medical Biology, University of Tromsø, Tromsø, Norway

R. L. Olsen Laboratory of Gastroenterology, Dept. of Medicine and Dept. of Surgery, University Hospital of Tromsø, and Institute of Medical Biology, University of Tromsø, Tromsø, Norway

Abstract

In six pigs intravenous administration of Escherichia coli endotoxin caused septic shock and a significant increase in serum cationic trypsin-like immunoreactivity (CTLI), with activation of cationic trypsinogen to trypsin and formation of complexes between cationic trypsin, on the one hand, and alpha₂-macroglobulin and alpha,-antitrypsin, on the other, compatible with acute pancreatitis. In contrast, intraduodenal infusion of E.coli endotoxin to seven other pigs was without effect on the general circulation and on the serum CTLI.

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Effect of Intravenous and Intraduodenal Administration of Escherichia Coli Endotoxin on the Porcine Pancreas as Evaluated by Changes in the Serum Cationic Trypsin-Like Immunoreactivity

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Effect of Intravenous and Intraduodenal Administration of Escherichia Coli Endotoxin on the Porcine Pancreas as Evaluated by Changes in the Serum Cationic Trypsin-Like Immunoreactivity

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