Effects of Intravenously Infused Porcine Gip on Serum Insulin, Plasma C-Peptide, and Pancreatic Polypeptide in Non-Insulin-Dependent Diabetes in the Fasting State

Abstract

Eight fasting patients with non-insulin-dependent diabetes (NIDD) and six healthy controls were given an intravenous infusion of porcine gastric inhibitory polypeptide (GIP). During the GIP infusion mean plasma pancreatic polypeptide level increased significantly in both groups, whereas the mean serum insulin level increased in the NIDD group only, indicating a more important role for GIP in these patients than in healthy subjects.

Key Words:

• C-peptide
• diabetes
• gastric inhibitory polypeptide (GIP)
• pancreatic polypeptide (PP)