The Microvasculature of the Small-Intestinal Mucosa of the Rat: Quantification of Hemodynamic Effects of Topically Applied Cimetidine, Ranitidine, Somatostatin, and Vasopressin

M. Neff Institute of Biomedical Engineering of the Swiss Federal Institute of Technology and the University of Zurich, Depts. of Medicine of the University Hospital, Zurich; Kreisspital, Männedorf, Switzerland

J. M. Meatry Institute of Biomedical Engineering of the Swiss Federal Institute of Technology and the University of Zurich, Depts. of Medicine of the University Hospital, Zurich; Kreisspital, Männedorf, Switzerland

P. Frick Institute of Biomedical Engineering of the Swiss Federal Institute of Technology and the University of Zurich, Depts. of Medicine of the University Hospital, Zurich; Kreisspital, Männedorf, Switzerland

M. Anliker Institute of Biomedical Engineering of the Swiss Federal Institute of Technology and the University of Zurich, Depts. of Medicine of the University Hospital, Zurich; Kreisspital, Männedorf, Switzerland

M. Knoblauch Institute of Biomedical Engineering of the Swiss Federal Institute of Technology and the University of Zurich, Depts. of Medicine of the University Hospital, Zurich; Kreisspital, Männedorf, Switzerland

Abstract

Neff M, Metry JM, Frick P, Anliker M, Knoblauch M. the microvasculature of the small-intestinal mucosa: quantification of hemodynamic effects of topically applied cimetidine, ranitidine, somatostatin, and vasopressin. Scand J Gastroenterol 1985, 20(suppl. 112), 6–11.

The influence of topically administered cimetidine, ranitidine, somatostatin, and vasopressin on microvessels of the jejunal villus of the rat was investigated by means of an in vivo videomicroscopy technique. for all substances a dose-response curve concerning the change of vessel diameters was obtained. All four drugs induced a significant vasoconstriction at the capillary level. Maximum vasoconstriction was achieved with vasopressin. These results strongly suggest the presence and possibly importance of H₂ receptors in the intestinal vascular bed of the rat.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Microvasculature of the Small-Intestinal Mucosa of the Rat: Quantification of Hemodynamic Effects of Topically Applied Cimetidine, Ranitidine, Somatostatin, and Vasopressin

Information for

Open access

Opportunities

Help and information

The Microvasculature of the Small-Intestinal Mucosa of the Rat: Quantification of Hemodynamic Effects of Topically Applied Cimetidine, Ranitidine, Somatostatin, and Vasopressin

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature