Moderate reduction of gastric acid secretion in the treatment of peptic ulcer disease

Abstract

Duodenal ulceration is presumed to be induced and maintained by imbalance between aggressive and defensive factors. Development of drugs for correction of this imbalance has recently concentrated on maximum inhibition of acid secretion e.g. via H₂-receptor antagonists but has led to re-evaluation of antacids and antimuscarinics. It has been shown that about the same percentage of ulcers can be healed using low antacid doses or antimuscarinics (e.g. pirenzepine) or doses of H₂-receptor antagonists which do not inhibit acid secretion maximally as can be healed using higher doses of H₂-receptor antagonists. Avoidance of the intragastric bacterial overgrowth and its consequences and the disturbance of the acid-gastrin feedback mechanism which may follow maximum gastric acid suppression could provide a rationale for use of anti-ulcer therapy based on moderate reduction of gastric acid secretion.

Key Words:

• Antacids
• Antimuscarinics
• Bacteria
• Cytoprotection
• H₂-receptor antagonists
• Nitrite
• ulcer treatment