Emerging strategies in ulcer therapy: Pumps and receptors

Abstract

The treatment of gastric and duodenal ulcers has recently been revolutionised. The reason for this is the increased knowledge of the physiology and biochemistry of the mucosae at the cellular and subcellular levels. In this article, we try to explain how the gastric parietal cell works, and how, based on that knowledge, we might be able to devise increasingly sophisticated tools for inhibition of acid secretion.

Key Words:

• Acetylcholine
• acid secretion
• gastrin
• histamine
• H⁺K⁺ATPase
• omeprazole
• gastric glands
• parietal cell