Effect of Somatostatin on ¹³³Xe Clearance from Colonic Mucosa before and after Local Nervous Blockade in Unanaesthetized Man

K. Agerskov Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

R. Bousfield Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

P. E. Mortensen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

J. Olsen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

J. Christiansen Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

Abstract

The effect of intravenous somatostatin bolus on mucosal and submucosal blood flow in six patients with colostomies was studied with the local ¹³³Xe clearance technique. Mucosal and submucosal blood flow decreased by 28% after somatostatin injection. After induction of local nervous blockade by infiltrating the labelled area of the mucosal membrane with lidocaine the reduction in blood flow caused by somatostatin was abolished. These observations suggest that the vasoconstrictor effect of somatostatin is mediated by neurogenic mechanisms.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Effect of Somatostatin on ¹³³Xe Clearance from Colonic Mucosa before and after Local Nervous Blockade in Unanaesthetized Man

Information for

Open access

Opportunities

Help and information

Effect of Somatostatin on 133Xe Clearance from Colonic Mucosa before and after Local Nervous Blockade in Unanaesthetized Man

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature

Effect of Somatostatin on ¹³³Xe Clearance from Colonic Mucosa before and after Local Nervous Blockade in Unanaesthetized Man