Inhibition of Basal and Betazole- and Sham-Feeding-Induced Acid Secretion by Omeprazole in Man

Abstract

The effect of omeprazole, given as a buffered solution, on basal acid secretion and that induced by betazole and sham feeding in healthy subjects were studied. The three series of experiments showed a dose-dependent acid reduction during the 2nd to 4th h after administration of omeprazole in doses of 10–60 mg, with almost complete inhibition by the highest dose. The ED₅₀ values were of the same magnitude for basal and stimulated acid secretion. This indicates that omeprazole is an equally potent inhibitor of both kinds of acid secretion irrespective of the manner in which the acid is activated.

Key Words:

• Gastric acid secretion
• healthy subjects
• omeprazole
• plasma concentrations
• single doses