Effect of Cimetidine on Gastric Mucosal Cell Proliferation in Man

L. B. Svendsen Dept. of Surgical Gastroenterology, Pathological Institute, Bispebjerg Hospital, and the Finsen Laboratory, Finsen Institute, Copenhagen, Denmark

O. Hart Hansen Dept. of Surgical Gastroenterology, Pathological Institute, Bispebjerg Hospital, and the Finsen Laboratory, Finsen Institute, Copenhagen, Denmark

J. K. Larsen Dept. of Surgical Gastroenterology, Pathological Institute, Bispebjerg Hospital, and the Finsen Laboratory, Finsen Institute, Copenhagen, Denmark

T. Pedersen Dept. of Surgical Gastroenterology, Pathological Institute, Bispebjerg Hospital, and the Finsen Laboratory, Finsen Institute, Copenhagen, Denmark

Aa. Johansen Dept. of Surgical Gastroenterology, Pathological Institute, Bispebjerg Hospital, and the Finsen Laboratory, Finsen Institute, Copenhagen, Denmark

Abstract

Seven duodenal ulcer patients were treated for 3 months with cimetidine. Before and after treatment endoscopic biopsy specimens were taken for autoradiographic estimation of cell proliferation in the gastric mucosa in the antral and fundic part of the stomach and from the duodenum. In all three areas the estimated labeling index was increased during medication with cimetidine. The increase in epithelial cell renewal may participate in the ulcer healing effect of cimetidine.

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Effect of Cimetidine on Gastric Mucosal Cell Proliferation in Man

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Effect of Cimetidine on Gastric Mucosal Cell Proliferation in Man

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