A Single-Centre Study of Gastric Ulcer Healing with 300 Mg Ranitidine at Night Versus 150 Mg Ranitidine Twice Daily

Abstract

Jorde R, Burhol PG. A single-centre study of gastric ulcer healing with 300 mg ranitidine at night versus 150 mg ranitidine twice daily. Scand J Gastroenterol 1986, 21, 833-836

In a single-centre study 59 patients with gastric ulcer were treated either with 300 mg ranitidine at night or with 150 mg ranitidine twice daily. After 4 and 8 weeks 73% and 97%, respectively, of those treated with 300 mg at night and 59% and 86% of those treated with 150 mg twice daily had complete ulcer healing. These differences between the two groups were not statistically significant. No serious side effects were seen. Ranitidine, 300 mg at night, appears to be at least as effective as the standard 150 mg twice daily regimen in the treatment of gastric ulcer.

Key Words:

• Gastric ulcer
• H2-receptor antagonists
• ranitidine