Relationship between Secretory IgA, IgA-Containing (C3-Fixing) Circulating Immune Complexes, and Complement Components (C3, C4) in Patients with Obstructive Jaundice

G. Ohshio Dept. of Pathology and Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

F. Furukawa Dept. of Pathology and Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

T. Manabe Dept. of Pathology and Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

T. Tobe Dept. of Pathology and Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

Y. Hamashima Dept. of Pathology and Dept. of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

Abstract

Serum secretory IgA, IgA-containing circulating immune complexes (IgA-CIC), complement components, and major immunoglobulins were measured in patients with biliary tract stones and/or tumors of the biliary tract or pancreas. The levels of secretory IgA and total IgA were increased in patients with and without obstructive jaundice. The levels of both C3 and C4 were significantly higher in patients with or without obstructive jaundice than in healthy controls. In patients with obstructive jaundice the increased levels of secretory IgA, total IgA, and IgA-CIC were correlated with the increase of C3 but not with that of C4.

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Relationship between Secretory IgA, IgA-Containing (C3-Fixing) Circulating Immune Complexes, and Complement Components (C3, C4) in Patients with Obstructive Jaundice

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Relationship between Secretory IgA, IgA-Containing (C3-Fixing) Circulating Immune Complexes, and Complement Components (C3, C4) in Patients with Obstructive Jaundice

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