Leukocyte Elastase α₁-Proteinase Inhibitor Complexes May Diagnose Pancreatic Abscesses Early

Abstract

Complexes of alpha₁-proteinase inhibitor and leukocyte elastase could be demonstrated by crossed immunoelectrophoresis of the peritoneal fluid from four patients who developed a pancreatic abscess during an attack of pancreatitis. No such complexes were seen in 69 patients with acute pancreatitis without an abscess. The complexes were demonstrable 2–3 days before the abscess was clinically evident. They may thus be diagnostically and therapcutically important. The appearance of these complexes denotes the liberation of large amounts of leukocyte elastase. This may help explain the pathophysiology and high mortality of the pancreatic abscess, since leukocyte elastase is known to cause degradation of all components of connective tissue and also degradation and activation of many components within the different cascade systems.

Key Words:

• Abscess
• alpha₁-antitrypsin
• granulocytes
• leukocytes
• pancreatic disease
• pancreatitis
• protease inhibitors