Effects of Omeprazole and Cimetidine on Mucosal Acid Secretion, Blood Flow and Oxygen Consumption in the Dog Ex Vivo Gastric Chamber

Abstract

The three classical receptors associated with control of gastric acid secretion (acetylcholine, gastrin and histamine-H₂) influence other cell types beside the parietal cells within the mucosal layer. Agents that inhibit parietal cell secretion, such as adrenergic hormones and prostaglandins, are also known to influence other cells in the mucosa, particularly the microvessels. Omeprazole is a potent inhibitor of gastric acid secretion with no known direct effect on any mucosal cell type other than the parietal cells. This property may enable the direct effects of certain agents on mucosal metabolic activity to be distinguished from the indirect effects resulting from parietal cell inhibition.