Structure and Function of the Dog Gastric Mucosa During and After a 1-Year Treatment with Omeprazole. I. Macro- and Microscopic Findings

Abstract

In addition to its stimulatory action on acid secretion, gastrin also exerts trophic effects on the oxyntic mucosa. An increase in serum gastrin levels may be evoked by compounds that inhibit gastric acid secretion, and it is conceivable that this might bring about changes in the structure of the gastric mucosa. The aim of the present study was to investigate whether long-term treatment with omeprazole results in any morphological changes in the canine gastric mucosa. Two dose regimens were used; one at therapeutic levels (2 μmol/kg) and another at extremely high doses (80 μmol/kg) of omeprazole.