Acid Secretory Capacity After Treatment with Omeprazole

B K Sharma Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

P Lundborg Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

R E Pounder Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

M Axelson Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

M Öhman Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

I A Santana Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

M Talbot Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

C Cederberg Academic Department of Medicine, Royal Free Hospital, London, UK and Research Laboratories AB Hässle, Mölndal, Sweden

show all

Abstract

Omeprazole, an H⁺K⁺ATPase inhibitor, is a potent suppressor of gastric acid secretion. A dose of 30 mg/day caused a 97% decrease of mean 24-hour intragastric acidity in duodenal ulcer patients. Basal and postprandial plasma gastrin concentrations were increased during once daily omeprazole treatment, but were reversed after cessation of treatment. The object of this study was to investigate whether this omeprazole induced elevation of plasma gastrin has a trophic effect on the parietal cell mass in man.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Acid Secretory Capacity After Treatment with Omeprazole

Information for

Open access

Opportunities

Help and information

Acid Secretory Capacity After Treatment with Omeprazole

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature