Effect of Oral Omeprazole on Fasting and Meal Stimulated Serum Gastrin and Serum Pepsinogen I Levels in Healthy Volunteers

H Festen Departments of Gastroenterology and Human Genetics, Free University Hospital, Amsterdam

J Thijs Departments of Gastroenterology and Human Genetics, Free University Hospital, Amsterdam

C Lamers Department of Gastroenterology, St Radboud Hospital, Nijmegen, The Netherlands

J Jansen Department of Gastroenterology, St Radboud Hospital, Nijmegen, The Netherlands

G Pals Departments of Gastroenterology and Human Genetics, Free University Hospital, Amsterdam

R Frants Departments of Gastroenterology and Human Genetics, Free University Hospital, Amsterdam

J Defize Departments of Gastroenterology and Human Genetics, Free University Hospital, Amsterdam

S Meuwissen Departments of Gastroenterology and Human Genetics, Free University Hospital, Amsterdam

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Abstract

Omeprazole is a potent, long acting inhibitor of gastric acid secretion. It acts by blocking the H⁺K⁺ATPase in the parietal cell. Intragastric neutralization causes a rise in serum gastrin levels and, after longer periods of time, hyperfunction of gastrin producing cells may result. Therefore, the effects and after-effects of oral omeprazole on fasting and meal stimulated serum gastrin and serum pepsinogen I levels were studied.

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Effect of Oral Omeprazole on Fasting and Meal Stimulated Serum Gastrin and Serum Pepsinogen I Levels in Healthy Volunteers

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Effect of Oral Omeprazole on Fasting and Meal Stimulated Serum Gastrin and Serum Pepsinogen I Levels in Healthy Volunteers

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