Cimetidine, 800 Mg at Night Versus 400 Mg Twice Daily, in the Treatment of Duodenal Ulcer

L. Capurso Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

P. R. Dal Monte Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

F. Mazzeo Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

G. Menardo Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

A. Morettini Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

A. Saggioro Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

G. Tafner Dept. of Gastroenterology, Ospedale S. Filippo Neri, Rome; Gastroenterology Unit, Ospedale Bellaria, Bologna; Unit of Gastroenterology and Digestive Endoscopy, Ospedale Borgonovo Valtidone, Piacenza; Division of Medicine, Dept. of Gastroenterology, Ospedale Pietra Ligure, Savona; Dept. of Gastroenterology, Ospedale Ponte Novo, Careggi, Florence; Gastroenterology Unit, Ospedale Generale Provinciale, Mestre, Venice; Gastroenterology Unit, Ospedale S. Chiara, Trento, Italy

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Abstract

A multicentre double-blind study was carried out on a total of 197 patients, to evaluate the safety and efficacy of an 800 mg nighttime dose of cimetidine in comparison with 400 mg twice daily in the treatment of duodenal ulcer. At 4 weeks 84% of the 187 patients eligible for analysis had healed ulcers with the once daily regimen and 68% with the twice daily regimen (p <0.05). An early decrease in both day and nighttime pain and in antacid consumption was observed during the first 2 weeks. Adverse effects were few and mild, confirming the safety profile of cimetidine.

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Cimetidine, 800 Mg at Night Versus 400 Mg Twice Daily, in the Treatment of Duodenal Ulcer

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Cimetidine, 800 Mg at Night Versus 400 Mg Twice Daily, in the Treatment of Duodenal Ulcer

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