Prevention of recurrent ulcer bleeding, a multicentre study of the: effect of ranitidine and trimipramine over one year

Abstract

Short term studies of the prevention of bleedings from Paptic; have been reported by a number of authors following treatment with ± H₂-receptor blockers, cimetidine (2-15), a combination of cimetidine and $ acid (16), cimetidine and somatostatin (17), cimetidine and sucralfate or $(18, 19, 20), cimetidine compared to antacid (21), and cimetidine $ antacid and pirenzepine (22). The H₂-blocker rantitidine has been compare to-placebo (24, 25, 26). An uncontrolled study has been performed using $ (27), a controlled study with vasopressin (28) and with secretin versus $(28). In the studies with H₂-receptor antagonists conflicting results have been obtained. No report has. been published concerning the effect ever $ days or weeks.

Key Words:

• Clinical trial
• Peptic ulcer
• Ranitidine
• Trimipramine