Dose response studies of gastric acid secretion in Nigerians Using Pentagastrin stimulation

Abstract

To determine the does of pentagastrin required for maximal gastric acid secretion, 6, 8, and 10ug/kg body weight of intramuscular pentagastrin were given to twenty Nigerian subjects (ten controls and ten duodenal ulcer patients). The different doies of pentagastrin were administered to each subject on different Days.

8μg/kg body weight of pentagastrin caused the highcsi gastric acid output in all the subjects followed by 6 and lastly 10ug/kg body weight. Significant differences in the mean stimulated acid output by 6 and 8ug/kg body weight to pentagastrin were found only in the duodenal ulcer patients (Maximal Acid Ouptut (M.A.O.).

Key Words:

• Duodenal ulcer
• gastric secretion
• pentagastrin