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Abstract
Dextran C (M.W. 60,000-70,000) employed as plasma expander in the treatment of hypovolemic shock, and which is known to induce histamine release from rat mast cells was studied for its effect on gastric acid secretion in rats. Dextran at doses even lower than the therapeutic dose in man (8-250mg/kg) induced significant gastric acid secretion in intact anaesthesized rats. Pretreatment of the animals with 1mg/kg cimetidine significanlty reduced the increase in acid secretion while a higher does of 10mg/kg completely abolished the effect. The result thus suggests that dextran-induced gastric acid secretion in rats is mediated through histamine release.