Effect of Acid Inhibition on Gastric Endocrine Cells

R. Arnold Division of Gastroenterology and Metabolism, Dept. of Internal Medicine, Philipps University, Marburg; BYK Gulden Pharmazeutika, Institute of Pathology and Toxicology, Hamburg, FRG

H. Koop Division of Gastroenterology and Metabolism, Dept. of Internal Medicine, Philipps University, Marburg; BYK Gulden Pharmazeutika, Institute of Pathology and Toxicology, Hamburg, FRG

H. Schwarting Division of Gastroenterology and Metabolism, Dept. of Internal Medicine, Philipps University, Marburg; BYK Gulden Pharmazeutika, Institute of Pathology and Toxicology, Hamburg, FRG

K. Tuch Division of Gastroenterology and Metabolism, Dept. of Internal Medicine, Philipps University, Marburg; BYK Gulden Pharmazeutika, Institute of Pathology and Toxicology, Hamburg, FRG

B. Willemer Division of Gastroenterology and Metabolism, Dept. of Internal Medicine, Philipps University, Marburg; BYK Gulden Pharmazeutika, Institute of Pathology and Toxicology, Hamburg, FRG

Abstract

There is increasing evidence that the numbers of antral G cells and of fundic argyrophil (ECL) cells are influenced by agents that inhibit gastric acid secretion. Antral G cells increase in states of achlorhydria in man and animals provided atrophic antral gastritis is absent. In rats, treatment with substituted benzimidazoles like omeprazole and BY 308 increase G-cell densities dose-dependently. Even high doses of histamine H-2 antagonists and antacids increase antral G-cell densities. In contrast to G cells, antral D cells decrease in these instances. Fundic ECL cells increase in all experimental conditions of complete achlorhydria provided intact antral mucosa is present, i.e. there is elevated serum gastrin. Antacid treatment is not followed by an increase of fundic ECL cells, which could be explained by the less sustained increase of serum gastrin.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Effect of Acid Inhibition on Gastric Endocrine Cells

Information for

Open access

Opportunities

Help and information

Effect of Acid Inhibition on Gastric Endocrine Cells

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature