The Effect of 20 Mg Omeprazole Daily on Serum Gastrin, 24-H Intragastric Acidity, and Bile Acid Concentration in Duodenal Ulcer Patients

J. Naesdal Dept. of Internal Medicine, University Hospital, Linköping; Dept. of Clinical Chemistry, University Hospital, Uppsala; Medical Dept., Hässle, Mölndal, Sweden

M. Bankel Dept. of Internal Medicine, University Hospital, Linköping; Dept. of Clinical Chemistry, University Hospital, Uppsala; Medical Dept., Hässle, Mölndal, Sweden

G. Bodemar Dept. of Internal Medicine, University Hospital, Linköping; Dept. of Clinical Chemistry, University Hospital, Uppsala; Medical Dept., Hässle, Mölndal, Sweden

R. Gotthard Dept. of Internal Medicine, University Hospital, Linköping; Dept. of Clinical Chemistry, University Hospital, Uppsala; Medical Dept., Hässle, Mölndal, Sweden

G. Lundquist Dept. of Internal Medicine, University Hospital, Linköping; Dept. of Clinical Chemistry, University Hospital, Uppsala; Medical Dept., Hässle, Mölndal, Sweden

A. Walan Dept. of Internal Medicine, University Hospital, Linköping; Dept. of Clinical Chemistry, University Hospital, Uppsala; Medical Dept., Hässle, Mölndal, Sweden

Abstract

Serum gastrin, 24-h intragastric acidity, and bile acid concentrations were measured during physiologic conditions in 10 patients with duodenal ulcer disease. Omeprazole, 20 mg daily, for 8 days reduced acidity by ⩾99% in six patients and by 47–54% in four patients. The degree of acid reduction was related to the area under the plasma omeprazole concentration time curve (AUC). Serum gastrin levels were not significantly increased by omeprazole. Intragastric bile acid concentrations were increased by omeprazole, but this seems to be of little importance for the healing of duodenal ulcers

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Effect of 20 Mg Omeprazole Daily on Serum Gastrin, 24-H Intragastric Acidity, and Bile Acid Concentration in Duodenal Ulcer Patients

Information for

Open access

Opportunities

Help and information

The Effect of 20 Mg Omeprazole Daily on Serum Gastrin, 24-H Intragastric Acidity, and Bile Acid Concentration in Duodenal Ulcer Patients

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature