The Immediate Effect of Human Renal Transplantation on Basal and Meal-Stimulated Levels of Gastrointestinal Hormones

J. Haffner Surgical Dept. B, Medical Dept. A, Pediatric Research Institute, Rikshospitalet, Norway; The National Hospital, University of Oslo, and Research Laboratory, Apotekernes Laboratorium, Oslo, Norway

P. Linnestad Surgical Dept. B, Medical Dept. A, Pediatric Research Institute, Rikshospitalet, Norway; The National Hospital, University of Oslo, and Research Laboratory, Apotekernes Laboratorium, Oslo, Norway

E. Schrumpf Surgical Dept. B, Medical Dept. A, Pediatric Research Institute, Rikshospitalet, Norway; The National Hospital, University of Oslo, and Research Laboratory, Apotekernes Laboratorium, Oslo, Norway

L. E. Hanssen Surgical Dept. B, Medical Dept. A, Pediatric Research Institute, Rikshospitalet, Norway; The National Hospital, University of Oslo, and Research Laboratory, Apotekernes Laboratorium, Oslo, Norway

O. Flaten Surgical Dept. B, Medical Dept. A, Pediatric Research Institute, Rikshospitalet, Norway; The National Hospital, University of Oslo, and Research Laboratory, Apotekernes Laboratorium, Oslo, Norway

S. Øyasteter Surgical Dept. B, Medical Dept. A, Pediatric Research Institute, Rikshospitalet, Norway; The National Hospital, University of Oslo, and Research Laboratory, Apotekernes Laboratorium, Oslo, Norway

Abstract

Elevated serum levels of gastrin, pancreatic polypeptide, and glucagon were found in 10 uraemic patients, whereas gastric inhibitory polypeptide and somatostatin levels were normal. After renal transplantation there was a significant reduction in serum gastrin (median, 5pmol/l; p = 0.05, n = 9), pancreatic polypeptide (145pmol/l; p < 0.01, n = 9), GIP (9.5 pmol/l;p = 0.02, n = 7), and glucagon (92pg/l;p < 0.02, n = 9), whereas no alteration was seen in the somatostatin level. Meal stimulation produced consistent increases in serum levels of all hormones, and the response appeared to be unchanged after renal transplantation.

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The Immediate Effect of Human Renal Transplantation on Basal and Meal-Stimulated Levels of Gastrointestinal Hormones

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The Immediate Effect of Human Renal Transplantation on Basal and Meal-Stimulated Levels of Gastrointestinal Hormones

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