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Abstract
The aim of our study was to examine the direct effect of somatostatin on histamine-and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10-11M to 10−6M) on half-maximal doses of histamine (10−6 M), pentagastrin (10−6 M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10−10M to 10−6 M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin M) inhibited histamine-stimulated (W6M) IF release by 69.9 ± 7.2% and the combination of histamine (10−6 M) and pentagastrin (10−6 M) by 64.2 ± 9.,1%. This is the first in vitro demonstration that somatostatin inhibits IF release.