In Vitro Tetraploidy in Patients with Ulcerative Colitis

L. B. Svendsen Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

J. O. Søndergaard Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

J. Hegnhøj Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

L. Hbjgård Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

K. B. Lauritsen Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

S. Bülow Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

T. Horn Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

B. Shannon Danes Dept. of Surgical Gastroenterology F, Bispebjerg Hospital, Bispebjerg; Dept. of Surgical Gastroenterology, Dept. of Internal Medicine, Division of Gastroenterology, and Dept. of Pathology, Hvidovre Hospital, Hvidovre; Dept. of Internal Medicine P, Division of Gastroenterology, Rigshospitalet, Copenhagen, Denmark; Laboratory for Cell Biology, Dept. of Medicine, Cornell University Medical School, New York, New York, USA

show all

Abstract

One hundred and seven patients (57 patients with ulcerative colitis and 50 controls) were investigated for in vitro tetraploidy (IVT) in dermal fibroblast monolayer cultures. There was no difference in incidence of IVT between patients with ulcerative colitis and controls. We advance the hypothesis that the genetic background of the colorectal cancer type found in ulcerative colitis differs from that found in the colon cancer syndromes and in non-hereditary colorectal cancers. Colorectal cancer in ulcerative colitis is probably only dependent on the degree of inflammatory lesions of the colonic mucosa.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

In Vitro Tetraploidy in Patients with Ulcerative Colitis

Information for

Open access

Opportunities

Help and information

In Vitro Tetraploidy in Patients with Ulcerative Colitis

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature