The Effects of 75 Mg HOE 760, a Novel H₂-Receptor Antagonist, on Daytime Peptone-Stimulated and Nocturnal Gastric Acid Output in Healthy Volunteers

F. Hagenmüller IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

C. Weber IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

S. Hausmann IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

R. Labs IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

V. Malerczyk IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

S. de Looze IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

M. Classen IInd Medical Clinic and Poliklinik rechts der Isar, Technical University of Munich, Munich, FRG; The Clinic of Johann-Wolfgang-von-Goethe University, Clinical Research Dept., Hoechst Aktiengesellschaft, Frankfurt, FRG

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Abstract

The effects of HOE 760, a highly specific H₂-receptor antagonist, on daytime peptone-stimulated and nocturnal gastric acid output were studied (randomized, double-blind crossover) in 10 healthy men. Acid output was monitored at lunch (1200 h to 1400 h) and dinnertime (1800 h to 2000 h) by continuous automatic intragastric titration; from midnight to 0600 h, output was measured by titration of manually aspirated gastric contents. After a 75-mg oral dose (capsule containing HOE 760 granules) at 0800 h peptone-stimulated acid output decreased for at least 12 h. Compared with placebo, significant reductions (p < 0.05) of 86% and 32% were observed 4–6 h and 10–12 h after drug administration. After another dose of 75 mg at 2100 h nocturnal acid output was significantly reduced (p < 0.05) by 88%; gastric pH was increased by about 2 units throughout the night. HOE 760 was well tolerated. No adverse reactions occurred; no clinically relevant changes were noted in haematologic, biochemical, urinary, or electrocardiographic variables.

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The Effects of 75 Mg HOE 760, a Novel H₂-Receptor Antagonist, on Daytime Peptone-Stimulated and Nocturnal Gastric Acid Output in Healthy Volunteers

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The Effects of 75 Mg HOE 760, a Novel H₂-Receptor Antagonist, on Daytime Peptone-Stimulated and Nocturnal Gastric Acid Output in Healthy Volunteers