An Approach to the Mechanism of Acute Ulceration in Obstructive Jaundice

T. Urakawa First Dept. of Surgery, School of Medicine, Kobe University, Kobe, Japan

Y. Nagahata First Dept. of Surgery, School of Medicine, Kobe University, Kobe, Japan

M. Nakamoto First Dept. of Surgery, School of Medicine, Kobe University, Kobe, Japan

K. Kumagai First Dept. of Surgery, School of Medicine, Kobe University, Kobe, Japan

Y. Saitoh First Dept. of Surgery, School of Medicine, Kobe University, Kobe, Japan

Abstract

Changes of noradrenaline (NA) and prostaglandin (PG) E₂ in gastric mucosa and gastric wall blood flow (GWBF) were investigated after stress load in rats with obstructive jaundice. We found that water immersion and restraint stress more easily increased the ulcer index and decreased GWBF, corresponding to a decrease of the NA and PGE₂ contents in the gastric mucosa, as the duration of jaundice increased. Administration of PGE₂ reduced the increase of the ulcer index and the decrease of the GWBF and NA contents in the gastric mucosa. It is suspected that the rapid decrease of NA and PGE₂ is connected with the rapid decrease of GWBF after stress load in obstructive jaundice, and we reached the hypothesis that both PGE₂ and NA mutually regulate local GWBF.

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An Approach to the Mechanism of Acute Ulceration in Obstructive Jaundice

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An Approach to the Mechanism of Acute Ulceration in Obstructive Jaundice

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