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Scandinavian Journal of Gastroenterology Volume 22, 1987 - Issue 8
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Original Article

Role of Endogenous Prostaglandins in Protection of Rat Gastric Mucosa by Tripotassium Dicitrate Bismuthate

S. Malandrino Research and Development Laboratories, Dompé Farmaceutici S.p.a., Milan, Italy; CNR Center Cytopharmacology, Dept. of Pharmacology, Milan, Italy; Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy
,
A. Bestetti Research and Development Laboratories, Dompé Farmaceutici S.p.a., Milan, Italy; CNR Center Cytopharmacology, Dept. of Pharmacology, Milan, Italy; Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy
,
G. Fumagalli Research and Development Laboratories, Dompé Farmaceutici S.p.a., Milan, Italy; CNR Center Cytopharmacology, Dept. of Pharmacology, Milan, Italy; Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy
,
M. Borsa Research and Development Laboratories, Dompé Farmaceutici S.p.a., Milan, Italy; CNR Center Cytopharmacology, Dept. of Pharmacology, Milan, Italy; Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy
,
T. Viganó Research and Development Laboratories, Dompé Farmaceutici S.p.a., Milan, Italy; CNR Center Cytopharmacology, Dept. of Pharmacology, Milan, Italy; Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy
&
G. Tonon Research and Development Laboratories, Dompé Farmaceutici S.p.a., Milan, Italy; CNR Center Cytopharmacology, Dept. of Pharmacology, Milan, Italy; Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy
Pages 943-948 | Received 11 Mar 1987, Accepted 12 May 1987, Published online: 08 Jul 2009
 
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Abstract

Gross and microscopic examination of rat gastric mucosa demonstrated that intra-gastric administration to rats of tripotassium dicitrate bismuthate (TDB), a colloidal bismuth compound, protects against gastric lesions induced by 85% ethanol. Indo-methacin, a prostaglandin synthetase inhibitor, significantly blocked the gastric mucosal protective effect of TDB. The release of gastric mucosal prostaglandins was greater in animals treated with TDB than in control animals, both time- and dose-dependently. These results seem to indicate involvement of prostaglandins in the action of TDB.

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