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Abstract
The effect ot morphine on bilixy dynamics was studied by cholescintigraphy with 99mTc-HIDA. Among 30 normals without morphine injection 3 did not demonstrate intestinal radioactivity after I h. whereas all visualized the gallbladder. Eight normals with morphine injection did nor demonstrate intestinal radioactivity after 2 h. hut all had gallbladder visualization wry early. Variables of the time-activity curves from liver areas did not point to impaired uptake or excretion. Morphine-induced increase in resistance to passage from the common duct to the intestines in normals is of a magnitude that forces the tutal amount of bile to accumulate in the gallbladder. Results from 11 patients aftcr chokcystectomy indicate that the increase in pressure illess than the nraximal secretory pressure of the liver. The resorptive capacity and the compliance of the gallblsdder cnable these events to take place without signs of secondary liver impairment.