Prostanoids in Jejunal Biopsy Specimens of Celiac Children with Active Disease and on Challenge Diet: Radioimmunologic Evaluation

R. Pietroletti Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

M. Castro Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

P. Mariani Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

V. Lucidi Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

M. D. D'alessandro Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

F. Carlei Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

D. Lomanto Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

E. Lezoche Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

V. Speranza Institute of the IInd Surgical Clinic, ‘La Sapienza’ University, and Gastroenterology Service, ‘Bambin Ges’ Hospital, Rome, Italy

show all

Abstract

Prostanoid generation (prostaglandin E, and thromboxane B₂) in jejunal biopsy specimens from celiac patients was evaluated, comparing celiac patients with celiac patients on challenge diet and controls. Generation of prostaglandin E, in jejunal specimens from 14 children with active celiac disease was significantly higher (341.8 ± 82.3 ng/g; mean ± SEM) than that from 7 celiac patients on gluten challenge diet (69.4 ± 13.2 ng/g) or 8 normal children (92 ± 23 ng/g) (p < 0.05). In contrast, thromboxane B, generation in jejunal specimens from all three groups did not show any statistically significant variation. Our results indicate that prostaglandin E₂ generation is not merely related to the activity of clinical symptoms, since patients receiving gluten challenge had prostaglandin E₂ levels that did not differ from those of controls.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Prostanoids in Jejunal Biopsy Specimens of Celiac Children with Active Disease and on Challenge Diet: Radioimmunologic Evaluation

Information for

Open access

Opportunities

Help and information

Prostanoids in Jejunal Biopsy Specimens of Celiac Children with Active Disease and on Challenge Diet: Radioimmunologic Evaluation

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature